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25 Years of P53 Research

Erschienen am 26.10.2007, Auflage: 1/2007
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Bibliografische Daten
ISBN/EAN: 9781402065644
Sprache: Englisch
Umfang: xii, 446 S.
Einband: kartoniertes Buch

Beschreibung

InhaltsangabeChapter 1: The First Twenty-Five Years of p53 Research; Harlan Robins, Gabriela Alexe, Sandra Harris and A.J. Levine Chapter 2: Regulation of p53 DNA Binding; Kristine McKinney and Carol Prives Chapter 3: 20 Years of DNA Damage Signaling to p53; Kevin G. McLure and Michael B. Kastan Chapter 4: Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX; Geoffrey M. Wahl, Jayne M. Stommel, Kurt Krummel and Mark Wade Chapter 5: Regulation of the p53 Response by Cellular Growth and Survival Factors; Lauren Brown and Samuel Benchimol Chapter 6: p53, Cell Cycle Arrest and Apoptosis; Shulin Wang and Wafik S. El-Deiry Chapter 7: p53 Has a Direct Pro-apoptotic Action at the Mitochondria; Ute M. Moll Chapter 8: Manipulating the p53 Gene in the Mouse: Organismal Functions of a Prototype Tumor Suppressor; Lawrence A. Donehower, Dora Bocangel, Melissa Dumble and Guillermina Lozano Chapter 9: p53, p63, and p73: Internecine Relations? Frank McKeon and Annie Yang Chapter 10: p73, p63 and Mutant p53: Members of Protein Complexs Floating in Cancer Cells; Olimpia Monti, Alexander Damalas, Sabrina Strano and Giovanni Blandino Chapter 11: p53: Gatekeeper, Caretaker or Both? Carlos P. Rubbi and Jo Milner Chapter 12: Analysis of p53 Gene Alterations in Cancer: A Critical View; Thierry Soussi Chapter 13: Patterns of TP53 Mutations in Human Cancer: Interplay Between Mutagenesis, DNA Repair and Selection; Hong Shi, Florence Le Calvez, Magali Olivier and Pierre Hainaut Chapter 14: Prognostic and Predictive Value of TP53 Mutations in Human Cancer; Magali Olivier, Pierre Hainaut and Anne-Lise Børresen-Dale Chapter 15: p53 Links Tumor Development to Cancer Therapy; Michael T. Hemann and Scott W. Lowe Chapter 16:Novel p53-Based Therapies: Strategies and Future Prospects; Sonia Lain and David Lane Chapter 17: Wild Type p53 Conformation, Structural Consequences of p53 Mutations and Mechanisms of Mutant p53 Rescue; Andreas C. Joerger, Assaf Friedler and Alan R. Fersht Chapter 18: Mutant p53 Reactivation as a Novel Strategy for Cancer Therapy; Galina Selivanova, Vladimir J.N. Bykov and Klas G. Wiman Chapter 19: Novel Approaches to p53-Based Therapy: ONYX-015; Frank McCormick Chapter 20: p53 as Seen by an Outsider; George Klein

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